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Dwight B. Wilmerding is only twenty-eight, but he’s creating a midlife crisis. He lives a dissolute existence in a tiny apartment with three (sometimes four) slacker roommates, holds a mind-numbing job at the pharmaceutical giant Pfizer, and has a chronic inability to constitute his mind. Encouraged by one of his roommates to try an experimental drug meant to banish indecision, Dwight jumps at the opportunity (not without some vacillation about the hazards of jumping) and swallows the first fateful pill. So when all at one time he is “pfired” by Pfizer and invited to a rendezvous in exotic Ecuador with the lady of his long-ago prep-school dreams, he finds himself on the brink of a fresh life. The trouble–well, one of the troubles–is the fact Dwight can’t decide if the pills will work. Deep in the jungles of the Amazon, in the foreign country of the changed outlook, his would-be romantic escape becomes a hilarious journey into unbidden responsibility and unwelcome knowledge–and an unexpected raison d’être.