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When Roland Doyle wakes up in an unfamiliar motel room with a bizarre man's finances in his pocket and a woman's deceased body in the bathroom, he worries the worst... and that is before he discovers the vial of pills labeled "take one every 4 hrs or else." If not what? Ten years back, Dr. Sebastian Briggs's medical drug trial for a cutting-edge fear-response drug went horribly incorrect - or achieved it? It's true any particular one trial participant died and five others were still left with no storage area of what happened to them. However now several interested people, including a significant pharmaceutical company and an ambitious U.S. senator, are willing to back Briggs's continuing research. All he has to do is remember his five making it through "volunteers," whose habit to a strange drug has still left them mainly at his removal. They will do anything essential to keep the pills coming and stave off the creeping phobias, powerful erotic impulses, and all-consuming madness that lurk on the ends of their minds. It's easy enough for the nice doctor to lure the survivors back again to the distant Monkey House, where the original trials occurred. However when the pills finally run out... the real show begins.