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For reclusive germophobe, Frank Talbot, coping with his crippling fear of contamination and germs has always been a challenge, but now he may have no choice. After a secret outbreak of an extremely lethal disease ravages the world and hundreds succumb to the contagious disease, the government instigates a cordon sanitaire in major places to contain it from spreading quickly around the country. At the onset of the epidemic, his ex-wife, Kate, an epidemiologist for the CDC, warns Frank and their child, Ella, to get ready for the most detrimental. The only desire of survival is retreating to their cottage on one of the isolated islands in the St. Lawrence River. Desperation breeds stress. Their survival will depend on fighting back and they're determined to make it through.