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In 1989, the charismatic Joshua Boger still left Merck, then America's most adored business, to found a medicine company that could task industry giants and transform health care. Barry Werth defined the business's tumultuous early days during the Helps crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he results in order to a riveting storyline of Vertex's strong stamina and eventual success. The $325-billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It is riskier plus more rigorous at only about every level than any business, from the towering biological uncertainties inherent in its mission to take care of disease; to the 30-to-1 failure rate in offering a successful medication even following a molecule clears all the hurdles to get to human trials; to the multibillion-dollar cost of ramping up an effective product; to operating in the world's most controlled industry, matched up only by nuclear power. Werth captures the full range of Vertex's 25-12 months drive to provide breakthrough medicines. At the same time when America struggles to keep up its innovative advantage, The Antidote is a robust inside look at one of the most intriguing and important business experiences of recent decades.