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Two teenagers struggle with a horrific family legacy, and the woman who has used them fights because of their lives - and her own. Adam and Alice are reaching the age when a few of the children created by the fertility treatment that spawned them commence to carefully turn feral. Will they succomb to the same physiological horror that demolished their parents? Every change brings on terror - the speech breaking as it changes, the swelling of the breasts, the coarsening of into actual hair. Their aunt, Cynthia, oversees renovations to the Twisden family's Manhattan house - torn apart by the children's parents at their most savage - and battles to give her niece and nephew the unconditional love they never had. Meanwhile, on earth outside, the forces of good and evil collide.
